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Multiple Sclerosis

Multiple sclerosis (MS) is an autoimmune disease affecting the body’s central nervous system. The immune system causes damage to nerve fibres and their myelin coating.

Research indicated that cannabis medicine s may be useful in relieving symptoms of MS such as:

  • Muscle Spasticity
  • Chronic Pain
  • Neuropathic Pain
  • Bladder Control Issues
  • Poor Sleep Quality
  • Limited Mobility 
  • Reduced Quality of Life

Differing forms of MS include: 

Relapsing-Remitting MS (RRMS) – Most common form of MS (affects nearly ¾ of MS patients). Periods of relapses/episodes are followed by periods of remission.

Secondary Progressive MS (SPMS) – Common in patients with RRMS. Patients experience progressively worsening periods of relapse and partial recovery.

Primary Progressive MS (PPMS) – Less common form of MS. Patients experience gradual and persistent worsening of symptoms. 

Clinically Isolated Syndrome (CIS) – A condition that can lead to MS. Inflammatory demyelination in the central nervous system produces neurologic symptoms.

01

Causes / Predispositions

The exact cause(s) of MS are unknown. Factors that may contribute to MS include:

  • Genetic Predisposition
  • Gender (More Common in Female Patients)
  • Environmental Factors
  • Age (Commonly Diagnosed Between Ages 20-40)
02

Symptoms

Common symptoms include: 

  • Muscle Spasticity
  • Chronic Pain
  • Neuropathic Pain
  • Feeling Stiff/Weak
  • Fatigue
  • Limited Mobility
  • Loss of Balance/Coordination
  • Loss of Focus/Concentration
  • Bladder Control Issues
  • Numbness/Tingling Sensations
  • Blurred Vision
  • Inability to Perform Activities of Daily Life
03

Traditional Treatments

While treatments can assist in managing symptoms, relieving attacks and/or slowing the progression of MS, there is currently no cure. 

Treatments and medications prescribed to patients with MS are dependent on factors such as the form of MS, severity of symptoms and complications due to additional medical conditions.

Medications

Muscle Spasticity:

  • Baclofen
  • Biperiden
  • Botulinum Toxins
  • Dantrolene
  • Diazepam
  • Trihexyphenidyl

Immunomodulators:

  • Alemtuzumab
  • Daclizumab
  • Dimethyl fumarate
  • Fampridine
  • Fingolimod
  • Glatiramer
  • Interferon beta
  • Natalizumab

Bladder Control:

  • Darifenacin
  • Oxybutynin
  • Solifenacin
  • Tolterodine 

Additional Medications/Treatments:

  • Analgesics (Opioids)
  • Corticosteroids Injection (Methylprednisolone) 
  • Laxatives
  • Stimulants (Caffeine)
04

Treatment with Cannabis Medicine

Additional research is needed to fully understand the therapeutic potentials and possible side effects of cannabis as a treatment for MS. Current research indicated that cannabis medicine may be a safe and effective alternative to traditional medications used in the treatment of MS. 

Cannabis medicine can be useful in relieving MS symptoms such as:

  • Muscle Spasticity
  • Chronic Pain
  • Neuropathic Pain
  • Bladder Control Issues
  • Poor Sleep Quality
  • Limited Mobility 
  • Reduced Quality of Life

 

Recommended Intake Method(s)

  • Edible Oils – Useful as a preventative treatment. Effectiveness limited by slow onset.
  • Inhalation via Vaporizer – Useful in achieving immediate symptom relief due to fast onset. 

Recommended Product Formulations

  • Products containing ratios of 1:1 THC to CBD.

Notable Terpenes

  • Caryophyllene (Anti-inflammatory, Muscle Spasms)
  • Myrcene (Analgesic, Sedating, Muscle Relaxant)
  • Linalool (Analgesic, Analgesic, Anti-Anxiety)