Ethan Russo: The Endocannabinoid System and Pharmacology of Hemp
Ethan Russo M.D Cornell University/USDA-ARS National Hemp Webinar Series March 23, 2022
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Conditions: Endocannabinoid System
Cannabidiol and the Endocannabinoid System: A Brief Tutorial
This short educational video provides a concise overview of the endocannabinoid system, along with important facts on the mechanisms of action of hemp oil constituents.
The effectiveness of inhaled Cannabis flower for the treatment of agitation/irritability, anxiety, and common stress
Background
An observational research design was used to evaluate which types of commonly labeled Cannabis flower product characteristics are associated with changes in momentary feelings of distress-related symptoms.
Endocannabinoid system in irritable bowel syndrome and cannabis as a therapy
Irritable bowel syndrome (IBS) global burden is underestimated despite its high prevalence. It’s a gastrointestinal disease having obscure pathophysiology with multiple therapies yet unsatisfactory remedies.
Cannabidiol in Anxiety and Sleep: A Large Case Series
Context
Cannabidiol (CBD) is one of many cannabinoid compounds found in cannabis. It does not appear to alter consciousness or trigger a “high.” A recent surge in scientific publications has found preclinical and clinical evidence documenting value for CBD in some neuropsychiatric disorders, including epilepsy, anxiety, and schizophrenia.
The endocannabinoid system in guarding against fear, anxiety and stress
The endocannabinoid (eCB) system has emerged as a central integrator linking the perception of external and internal stimuli to distinct neurophysiological and behavioural outcomes (such as fear reaction, anxiety and stress-coping), thus allowing an organism to adapt to its changing environment.
Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System
The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases.
The endocannabinoid system in pain and inflammation: Its relevance to rheumatic disease
Pain is the most common manifestation of both acute and chronic inflammation that often challenges patients with rheumatic disease. Simply, we attribute this to local joint changes of pH in joints, the formation of radicals, enhanced joint pressure, or cytokine release acting on local nerves to produce pain.
Dose-related effects of delta-9-THC on emotional responses to acute psychosocial stress
Objectives
Cannabis smokers often report that they use the drug to relax or to relieve emotional stress. However, few clinical studies have shown evidence of the stress-relieving effects of cannabis or cannabinoid agonists.
Cannabinoid CB1 and CB2 Receptor Signaling and Bias
An agonist that acts through a single receptor can activate numerous signaling pathways. Recent studies have suggested that different ligands can differentially activate these pathways by stabilizing a limited range of receptor conformations, which in turn preferentially drive different downstream signaling cascades.
