Fundamentally, this course will provide a grounding in the principles of evidence-based medicine and apply those principles to medical cannabis. This will include an extended introduction into the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) approach. In addition, the course will systematically examine the evidence for using cannabis for treating pain, spasticity, nausea, sleep, and psychiatric disorders, such as autism, anxiety, addiction, post-traumatic stress disorder, and schizophrenia. Finally, the course will review promising future directions in medicinal cannabis, including both novel cannabinoid medicines and novel treatment applications.